Discharge from metronidazole gel

Bacterial vaginosis (BV) is the most common cause of abnormal vaginal discharge. Additional symptoms of BV include vaginal odor and a burning sensation. BV also increases the risk of acquiring sexually transmitted infections, such as HIV. Anyone with symptoms that could be related to BV should be evaluated by a health care provider.

Normal vaginal discharge is clear or milky and thin. Thick, clumpy, or yellow discharge is abnormal and may signal an infection. Menu. Health A-Z COVID-19; Arthritis; ... Reisman HA, et al. Metronidazole vaginal gel 1.3% in the treatment of bacterial vaginosis: a dose-ranging study. J Low Genit Tract Dis. 2015;19(2):129-134. …Nov 7, 2022 · Summary. Metronidazole gel, cream, and lotion is a topical medication prescribed for the treatment of rosacea (a type of skin rash), and vaginal bacterial infections like bacterial vaginosis and vaginitis. Metronidazole interacts with alcohol and can produce disulifiram reactions, which causes side effect symptoms of severe flushing. I took metronidazole gel for 5 consecutive days to treat vaginosis. Two days after I am noticing thick clots of discharge which seem to be lessening and now I am getting mild cramps and discomfort in my lower abdomen. Also, it looks like I am spotting blood that's bright red.thick, white vaginal discharge with no odor or with a mild odor Less common. Burning on urination or need to urinate more often burning or irritation of the penis of the sexual partner feeling of vaginal pressure itching, pain, stinging, or redness of the genital area Some side effects may occur that usually do not need medical attention.When your reproductive system is functioning properly, it naturally clears out the old stuff to make room for the new. And vaginal discharge can run a spectrum of colors, from healthy to ...Intravaginal administration: Vaginal discharge, symptomatic Candida cervicitis/vaginitis, fungal infection, vulvovaginal irritation, dysmenorrhea, GI effects (abdominal pain, GI discomfort, ... Following intravaginal administration of 5 g of 0.75% vaginal gel (approximately 37.5 mg of metronidazole) in healthy women, peak serum …It can be used alone or as an adjunct therapy with the antibiotic metronidazole to treat bacterial vaginosis. ... discharge, use one tube daily for seven days.

It may help to decrease itching, discharge and other symptoms. Metronidazole is an antibiotic that works by stopping the growth of bacteria. HOW TO USE: This medication is for vaginal use only. Learn the correct way to apply this medication by reading the instructions on the product package. Use as directed, usually once or twice daily.Dec 13, 2017 · Note: as with metronidazole tablets, you should avoid alcohol while using metronidazole gel and for at least 48 hours after stopping treatment, although the tendency of the gels to make you feel sick are not as noticeable as for the tablets. Vaginal creams and gels can weaken latex condoms and diaphragms. Metronidazole vaginal gel is a gelled, purified water solution, containing metronidazole at a concentration of 7.5 mg/g (0.75%). The gel is formulated at pH 4.0. The gel also contains carbomer homopolymer type B, edetate disodium, methylparaben, propylparaben, propylene glycol, and sodium hydroxide. Each applicator full of 5 grams of vaginal ... "I was prescribed the metronidazole vaginal gel for bacterial vaginitis. They have me using the gel before bed for 5 days. Tonight will be my 4th night of use. So far the only side effects I have noticed are a very think, white discharge and menstrual like cramps and discomfort in my pelvic area. I also have had a slight decrease in my appetite.Metronidazole vaginal gel is indicated in the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, Corynebacterium vaginitis, or anaerobic vaginosis).. NOTE: For purposes of this indication, a clinical diagnosis of bacterial vaginosis is usually defined by the presence of a …

If you are allergic to metronidazole vaginal gel; any part of metronidazole vaginal gel; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have taken disulfiram within the past 2 weeks. If you are breast-feeding. Do not breast-feed for some time after getting metronidazole vaginal gel.Adults—One applicatorful (5 grams [g]) inserted into the vagina once a day (at bedtime) for 5 days. Each applicatorful of Vandazole® contains 37.5 mg of metronidazole. Children—Use and dose must be determined by your doctor. For vaginal dosage form (tablets): Adults—One 500 milligram (mg) tablet, inserted high into the vagina.Metronidazole topical gel is used to treat inflammatory lesions (pimples and red bumps) caused by rosacea. Rosacea is a skin disease that causes redness and pimples on your nose, cheeks, chin, and forehead. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Metronidazole. 400 mg or 500 mg, orally, twice daily for 7 days. Tinidazole 2 grams orally, single dose. or. Tinidazole 500 mg orally, twice daily for 5 days. Metronidazole 200 mg or 250 mg, orally, 3 times a day for 7 days. or. Metronidazole gel 0.75%, one full applicator (5 grams) intravaginally, twice a day for 7 days. C. albicans (yeast ... Hello, Vaginal discharge is a side effect of metronidazole gel which is present in 12% of the patients. If the discharge persists or there is any vulvar irritation or itching then you should get it evaluated from your gynecologist. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is ...If you’re in the market for a new mattress, you might be wondering what the difference is between memory foam and gel mattresses. Both types of mattresses offer a variety of benefi...

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A new formulation of MVG offers a higher concentration of metronidazole (1.3%) with a shorter treatment course and similar efficacy as MVG 0.75%. This study evaluated the efficacy and safety of MVG 1.3% once daily for 1, 3, or 5 days versus MVG 0.75% once daily for 5 days in the treatment of patients with BV. Go to:Finished treatment of metronidazole gel and noticed white clumpy discharge wen i wiped is it normal? Dr. Heidi Fowler answered. Psychiatry 27 years experience. Possibly Yeast: A clumpy (cottage cheese- like), white, non- odorous discharge associated w itching, burning, swelling or redness can be due to yeast infections. Metronidazole. 400 mg or 500 mg, orally, twice daily for 7 days. Tinidazole 2 grams orally, single dose. or. Tinidazole 500 mg orally, twice daily for 5 days. Metronidazole 200 mg or 250 mg, orally, 3 times a day for 7 days. or. Metronidazole gel 0.75%, one full applicator (5 grams) intravaginally, twice a day for 7 days. C. albicans (yeast ... Gel nail polish has become increasingly popular due to its long-lasting and chip-free formula. However, when it comes time to remove gel nail polish, many people make common mistak...Mar 1, 2024 · thick, white vaginal discharge with no odor or with a mild odor. Less common. Burning on urination or need to urinate more often. burning or irritation of the penis of the sexual partner. feeling of vaginal pressure. itching, pain, stinging, or redness of the genital area. Some side effects may occur that usually do not need medical attention.

Metronidazole vaginal gel is the intravaginal dosage form of the synthetic antibacterial agent, metronidazole, USP at a concentration of 0.75%. Metronidazole is a member of the imidazole class of antibacterial agents and is classified therapeutically as an antiprotozoal and antibacterial agent. ... Reproductive: Vaginal discharge (12% ...continuing stomach pain. diarrhea. feeling of warmth. increased volume of pale, dilute urine. joint or muscle pain. loss of bladder control. red skin lesions, often with a purple center. red, irritated eyes. redness of the face, neck, arms, and …FDA Prescribing Information. Topical metronidazole is an antibiotic used for the treatment of bacterial vaginal infections, and the skin condition rosacea. Topical …After using metronidazole gel when will the chunky white discharge disappear? A doctor has provided 1 answer. Dr. Heidi Fowler answered. Specializes in Psychiatry. Might have a yeast: infection which may need to be treated.Yeast can present with clumpy, white vaginal discharge to a watery, white discharge. Sometimes a discharge is not apparent.Nov 17, 2012 · Hot water will throw ph off as well lukewarm temp is fine. AS. Ashcash 3 Aug 2018. Dose Metronidazole clear your tubs out so that you can have baby. +0. MY. MynameisD 22 June 2018. I just finished my last dose yesterday and I noticed on the 4th treatment I have white thick discharge. No itching or burning. The most common side effects of metronidazole vaginal gel, cream, and lotion include: Skin irritation including mild dryness or burning sensation; Itching; Nausea; Metallic taste in the mouth; Headache (vaginal gel only) Vaginal discharge (vaginal gel only) Yeast infection (vaginal gel only) Yeast infectionsMetronidazole Vaginal Gel is the intravaginal dosage form of the synthetic antibacterial agent, metronidazole, USP at a concentration of 0.75%. Metronidazole is a member of the imidazole class of antibacterial agents and is classified therapeutically as an antiprotozoal and antibacterial agent.A: It is generally recommended to avoid sexual activity while experiencing clumpy discharge after using metronidazole gel. This is to prevent any potential ...Physicians prescribe metronidazole 400 mg tablets to treat and prevent certain kinds of infections, according to the National Health Service. These include mouth, bone, intestine a...Question posted by sydneyburns on 9 Nov 2014. Last updated on 21 December 2014 by SHEsevEN4. After the 2nd day of using Metro gel for BV I started to have brown discharge sometimes white clumpy discharge too. I have used all the metro gel as prescribed I have stopped taking the metro gel since last Tuesday.Topical metronidazole is an antibiotic used for the treatment of bacterial vaginal infections, and the skin condition rosacea. Topical metronidazole is available in gel, cream, and lotion forms. Disulfiram reactions can occur if you drink alcohol while using metronidazole. Symptoms of disulfiram reactions include severe flushing that may be accompanied by abnormal heart rhythms and hypotension ...

Applies to metronidazole topical: topical cream, topical gel/jelly, topical lotion. Other dosage forms: vaginal gel/jelly; Serious side effects of MetroGel. Along with its needed effects, metronidazole topical (the active ingredient contained in MetroGel) may cause some unwanted effects.

vaginal discharge. Serious side effects can occur while taking metronidazole tablets or capsules. These are all rare, however. Cancer: Metronidazole …DARK BROWN, ALMOST BLACK DISCHARGE while using METRONIDAZOLE VAGINAL GEL metronidazole vaginal gel metronidazole gel and bleeding Brown discharge with Bacterial Vaginosis - Finished Metronidazole and still have brown discharge taking metronidazole and passing a lot of white discharge Metronidazole Vaginal Gel for BV Dried up vaginal discharge ...Vaginal discomfort/itching/discharge may occur or worsen. These symptoms may be due to a new vaginal infection (such as a yeast/fungal infection). Contact your ...Metronidazole Vaginal Gel is indicated in the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, Corynebacterium vaginitis, or anaerobic vaginosis).. NOTE: For purposes of this indication, a clinical diagnosis of bacterial vaginosis is usually defined by the presence of a … It may help to decrease itching, discharge and other symptoms. Metronidazole is an antibiotic that works by stopping the growth of bacteria. HOW TO USE: This medication is for vaginal use only. Learn the correct way to apply this medication by reading the instructions on the product package. Use as directed, usually once or twice daily. Last updated on Sep 7, 2023. Uses. Before taking. Warnings. Dosage. Side effects. Overdose. Uses of Metronidazole Vaginal Gel: It is used to treat vaginal infections. It …Metronidazole vaginal gel USP, 0.75% affords minimal peak serum levels and systemic exposure (AUC) of metronidazole compared to 500 mg oral metronidazole dosing. Although these lower levels of exposure are less likely to produce the common reactions seen with oral metronidazole, the possibility of these and other reactions cannot be excluded ...To treat bacterial vaginosis, your doctor may prescribe one of the following medicines: Metronidazole (Flagyl, Metrogel-Vaginal, others). This medicine comes as a pill or topical gel. You swallow the pill, but the gel is inserted into your vagina. Avoid alcohol while using this medicine and for a full day afterward.

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headache. itching, scaling, severe redness, soreness, or swelling of the skin. joint pain. loss of appetite. loss of voice. lower back or side pain. muscle aches and pains. nausea. pounding in the ears.Question posted by mrs worries on 30 Aug 2012. Last updated on 28 December 2012 by Le Ella May. I recently finished a 5 night treatment of metronidazole vaginal gel and now I am experiencing big clumps of thick, white, gel-like excretions. I don't think it is a yeast infection because I do not have any burning or itching.Mar 26, 2015 · A new formulation of MVG offers a higher concentration of metronidazole (1.3%) with a shorter treatment course and similar efficacy as MVG 0.75%. This study evaluated the efficacy and safety of MVG 1.3% once daily for 1, 3, or 5 days versus MVG 0.75% once daily for 5 days in the treatment of patients with BV. Go to: My primary care told me about the existence of the metro gel, and prescribed me a 5-day course of that. It was fine, no real side affects till the last two days. I was having clumpy white discharge along with the gray-ish white discharge I originally had, along with some cramping. Depending on the brand, vaginal discharge can be a possible side effect of metronidazole vaginal gel. It should go away soon after completing a full course of treatment. If it doesn't, let your provider know.My doctor prescribed me metronidazole vaginal gel 0.75% once a day for 5 days for my BV. And it is my first day using it but I noticed clumps of white discharge coming out and it has an odor.Objective . Metronidazole vaginal gel (MVG) 0.75% is a US Food and Drug Administration–approved, 5-day treatment for bacterial vaginosis (BV). This study tested the hypothesis that a shorter treatment course at a higher dose (MVG 1.3%) would yield similar efficacy to 5 days of MVG 0.75%.Flagyl Metronidazole Buy Online. When it comes to purchasing medications online, Flagyl (metronidazole) is a commonly sought after antibiotic. This article will provide valuable information on buying Flagyl online, including understanding the medication, the benefits of online purchase, finding a reliable intеrnet pharmacy, prescription rеquirements, safety precautions, dоsage and ...Bacterial vaginosis (BV) is a common cause of abnormal vaginal discharge in women of childbearing age and affects 30% of women globally ().BV is a polymicrobial syndrome (dysbiosis) characterised by a profound change in the vaginal microbiota from a lactobacilli dominant state to one with high diversity and quantities of anaerobic bacteria including …A new formulation of MVG offers a higher concentration of metronidazole (1.3%) with a shorter treatment course and similar efficacy as MVG 0.75%. This study evaluated the efficacy and safety of MVG 1.3% once daily for 1, 3, or 5 days versus MVG 0.75% once daily for 5 days in the treatment of patients with BV. Go to:Metronidazole vaginal gel is indicated in the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, Corynebacterium vaginitis, or … ….

Metronidazole.75% was used to treat pt thick clear vaginal discharge with back pain and used for a week prescribed by the doctor. her symptoms stopped. however 3 weeks later symptoms are showing again. any suggestions on what to do next? thank you! A doctor has provided 1 answer.Topical Metronidazole is an antibiotic gel used on the skin to treat a kind of adult acne known as rosacea. Vaginal Metronidazole, on the other hand, is an antibiotic gel used to treat BV and other bacterial infections in the vagina. Common side effects of topical and vaginal Metronidazole include: For topical metronidazole. Skin irritation ...Gel nail polish has become increasingly popular due to its long-lasting and chip-free formula. However, when it comes time to remove gel nail polish, many people make common mistak...Question posted by sydneyburns on 9 Nov 2014. Last updated on 21 December 2014 by SHEsevEN4. After the 2nd day of using Metro gel for BV I started to have brown discharge sometimes white clumpy discharge too. I have used all the metro gel as prescribed I have stopped taking the metro gel since last Tuesday.vaginal discharge. Serious side effects can occur while taking metronidazole tablets or capsules. These are all rare, however. Cancer: Metronidazole …TMI. I was told i had a barteria infection and was proscribed this Metronidazole Gel. About two days into my treatment i noticed thick white discharge. I…Dec 5, 2022 · Typical dosing for Metronidazole vaginal gel. Nuvessa (metronidazole 1.3%) vaginal gel: The typical dose is to insert 1 applicatorful into the vagina at bedtime as a one-time dose. Vandazole (metronidazole 0.75%) vaginal gel: The typical dose is to insert 1 applicatorful into the vagina daily at bedtime for 5 days. Sodium hyaluronate eye drops are used to treat dry eyes and other dry eye conditions. An eye lubricant, sodium hyaluronate has many uses, read about them at Patient Try our Symptom... Discharge from metronidazole gel, Crushed tablets effectively eradicated odor for our patient with MCC, whereas gel could not. The price of a 500-mg metronidazole tablet ranges from $0.20 to $0.65, making this a cost-effective treatment compared with commercially available metronidazole gel, which 1 study estimated to cost $518.40 for 2 weeks of treatment. 12., Metronidazole gel USP, 1% is a nitroimidazole for topical use. Metronidazole gel USP, 1% is a clear, colorless to pale yellow, aqueous gel. Each gram contains 10 mg of metronidazole. Chemically, metronidazole is 2-methyl-5-nitro-1 H -imidazole-1-ethanol. The molecular formula for metronidazole is C 6 H 9 N 3 O 3., continuing stomach pain. diarrhea. feeling of warmth. increased volume of pale, dilute urine. joint or muscle pain. loss of bladder control. red skin lesions, often with a purple center. red, irritated eyes. redness of the face, neck, arms, and …, Dec 13, 2017 · Note: as with metronidazole tablets, you should avoid alcohol while using metronidazole gel and for at least 48 hours after stopping treatment, although the tendency of the gels to make you feel sick are not as noticeable as for the tablets. Vaginal creams and gels can weaken latex condoms and diaphragms. , Last updated on May 9, 2022. Metronidazole starts to work 1 to 2 hours after you take it, because it is quickly absorbed, and it reaches its maximum concentration after 20 minutes to 3 hours. But it may take a couple of days before you start to feel better or notice an improvement in your symptoms. It is important that you still finish the ..., Anonymouss101 6 Dec 2014. Im currently using this gel to treat BV. Also currently experiencing thick white cottage cheese like discharge w/ no smell. It was scaring me because I also have experienced yeast and completely hate it, but the fact that it's only discharge and no discomfort I'm hoping its just the gel doing work., 25 Apr 2024 ... Other treatment methods include metronidazole taken at 500 mg/day orally twice a day for a week, metronidazole gel (5 g) applied intravaginally ..., Question posted by sydneyburns on 9 Nov 2014. Last updated on 21 December 2014 by SHEsevEN4. After the 2nd day of using Metro gel for BV I started to have brown discharge sometimes white clumpy discharge too. I have used all the metro gel as prescribed I have stopped taking the metro gel since last Tuesday., Metronidazole gel or clindamycin vaginal cream for 7 days can also be considered for symptomatic women who are not undergoing gynaecological procedures. Single ..., Weird discharge after day 1 of metronidazole gel. Last night was my first of 5 nights taking metro gel vaginally. I’m due to insert again tonight but now I’m having a weird clumpy discharge. No odor or anything. But now I’m scared that I have a yeast infection. It’s nighttime now so I’ll have to wait until tomorrow to contact my doctor., 1 Apr 2020 ... BETAFEM® BV Gel is clinically proven ... Vaginal Discharge Colours | Is My Discharge ... How Long Does Metronidazole Take To Cure Trichomoniasis., My primary care told me about the existence of the metro gel, and prescribed me a 5-day course of that. It was fine, no real side affects till the last two days. I was having clumpy white discharge along with the gray-ish white discharge I originally had, along with some cramping. , As the subject says... Been using it for 5 days out of 7 and noticed that it hasn't helped the BV smell or uncomfortable feeling. Noticed a white chunky discharge last night and was wondering if this is normal?, The recommended dose is one applicator full of metronidazole vaginal gel (approximately 5 grams containing approximately 37.5 mg of metronidazole) intravaginally once or twice a day for 5 days ... Metronidazole vaginal gel, 0.75% is supplied in a 70 g tube and packaged with 5 vaginal applicators. The NDC number for the 70 g tube is 21922-039-23., The metronidazole vaginal gel achieves 2% of the mean maximum serum concentration of a 500 mg oral metronidazole ... Subjects had a clinical diagnosis of bacterial vaginosis defined by the presence of a homogenous vaginal discharge that (a) had a pH ≥ 4.7, (b) emitted a “fishy” amine odor when mixed with a 10% KOH solution (“whiff ..., Feb 2, 2023 · Metronidazole vaginal gel is used to treat bacterial vaginosis (infection of the vagina) caused by certain bacteria. By applying the gel directly into the vagina, metronidazole can kill the bacteria at the site of the infection. However, It is not suitable for all types of vaginal infections. , Metronidazole comes in gel, cream, and lotion forms and is applied to the skin one or two times a day. The affected skin should be washed with mild soap 15-20 minutes before applying metronidazole. The gel, cream, or lotion should be applied in a thin layer and gently rubbed into the skin. Moisturizers and cosmetics may be applied …, Metronidazole topical gel is used to treat inflammatory lesions (pimples and red bumps) caused by rosacea. Rosacea is a skin disease that causes redness and pimples on your nose, cheeks, chin, and forehead. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms:, Metronidazole is used to treat bacterial infections in different areas of the body. It is also used to treat infections caused by protozoa (eg, trichomoniasis and amebiasis) and infections caused by bacteria that do not need oxygen to survive. The extended-release tablets are used to treat women with vaginal infections (bacterial …, But there are other causes of blood-tinged brown discharge, too. She explains. 1. Menopause-related changes. When you’re in menopause, a decrease in estrogen can cause the walls of your vagina ..., VANDAZOLE ® (metronidazole gel), for intravaginal use Initial U.S. Approval: 1963. ... A clinical diagnosis of bacterial vaginosis was defined by the presence of a homogeneous vaginal discharge that (a) has a pH of greater than 4.5, (b) emits a "fishy" amine odor when mixed with a 10% KOH solution, and (c) contains clue cells on …, White discharge while taking metronnidazole? no itching, no smell. it never actually comes out on its own i only see it when i pull out the applicator. im taking metronidazole for my abnormal white discharge i took 3 pills already but it increases my dschrge, what does this mean?: Bacterial Vaginosis: Keep taking the medication till it is done ..., Metronidazole: Yeast can present with clumpy, white vaginal discharge to a watery, white discharge. Sometimes a discharge is not apparent. There is no odor. It can cause swelling and redness of vulva along with itching and burning pain. It may lead to pain with urination or intercourse. Get checked to rule out yeast infection which would …, What Zidoval gel contains. The active substance is metronidazole. Each gram of gel contains 7.5 mg of metronidazole. The other ingredients are: Carbopol 974P, disodium edetate, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), propylene glycol (E1520), sodium hydroxide (E524) and purified water., After using metronidazole gel when will the chunky white discharge disappear? A doctor has provided 1 answer. Dr. Heidi Fowler answered. Specializes in Psychiatry. Might have a yeast: infection which may need to be treated.Yeast can present with clumpy, white vaginal discharge to a watery, white discharge. Sometimes a …, Metronidazole.75% was used to treat pt thick clear vaginal discharge with back pain and used for a week prescribed by the doctor. her symptoms stopped. however 3 weeks later symptoms are showing again. any suggestions on what to do next? thank you! A doctor has provided 1 answer., When it comes to hair care, men often don’t pay as much attention as women do. However, just like women, men also need to take care of their hair and scalp to keep them healthy and..., It seems like my BV came back because of the discharge and burning. I was prescribed metronidazole gel to take at night for 5 days. I’ve taken it before and experienced zero problems, but this time I’m experiencing extremely painful burning the morning after taking a dose. It also burns when I pee., Metronidazole vaginal gel is indicated in the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, Corynebacterium vaginitis, or anaerobic vaginosis).. NOTE: For purposes of this indication, a clinical diagnosis of bacterial vaginosis is usually defined by the presence of a …, Treatment. To treat bacterial vaginosis, your doctor may prescribe one of the following medicines: Metronidazole (Flagyl, Metrogel-Vaginal, others). This medicine …, Basically, I went to Planned Parenthood after noticing abdominal pain and my IUD strings were much longer than they normally were. NP tested me for BV (came back positive) and prescribed metronidazole gel. I completed the 5-day course of treatment but have noticed really weird discharge., Dec 13, 2017 · Note: as with metronidazole tablets, you should avoid alcohol while using metronidazole gel and for at least 48 hours after stopping treatment, although the tendency of the gels to make you feel sick are not as noticeable as for the tablets. Vaginal creams and gels can weaken latex condoms and diaphragms. , For symptomatic women: Oral metronidazole is the treatment of choice. Intravaginal metronidazole gel or intravaginal clindamycin cream are alternative choices.