Trazodone and hydroxyzine

Drugs with possible benefit in these patients include trazodone , gabapentin , ... Hosseini SM, et al. Comparing the effect of prazosin and hydroxyzine on sleep quality in patients suffering from posttraumatic stress disorder. Neuropsychobiology 2014; 69:235. Raskind MA, Peskind ER, Chow B, et al. Trial of Prazosin for Post-Traumatic Stress ...

Trazodone and hydroxyzine. Trazadone and Hydroxyzine . I have been dealing with insomnia for a really long time and was prescribed hydroxyzine (50mg), but it did nothing for me, so my doctor prescribed me Tradazone (50mg) and it didn’t work either. ... i'm on 100mg of trazodone. that's been my dose over a year now. always works for me.

Summary. Sleep apnea is a sleeping disorder marked by interruptions in breathing during sleep. Certain medications, such as antihistamines, benzodiazepines, barbiturates, and opiates, can impact your natural sleeping cycle and breathing. This can increase your risk for developing sleep apnea or worsen the condition if you have it.

Introduction. Although psychiatric drug withdrawal syndromes have been recognized since the 1950s – recent studies confirm antidepressant withdrawal syndrome incidence upwards of 40% – medical information about how to safely go off the drugs has been lacking. 1 –4 To fill this gap, over the last 25 years, patients have developed a robust Internet-based subculture of volunteer peer ...Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the mouth, stuffy nose, constipation, or change ...Mirtazapine has an average rating of 6.8 out of 10 from a total of 2024 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 21% reported a negative effect. Trazodone has an average rating of 6.3 out of 10 from a total of 1410 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative ...What’s really needed, many conservationists believe, is a complete reboot to the way the world approaches wildlife protection in Africa. Kafue National Park in the heart of Zambia ...Other first-generation antihistamines (e.g., meclizine, hydroxyzine, dimenhydrinate, triprolidine) are also likely to be used for insomnia given their sedative effects but are not FDA approved for this indication. ... polypharmacy, and increased pill burden. Trazodone is not a controlled substance and is expected to have low cost given its ...Escitalopram, the (S)-enantiomer of citalopram, is a highly selective serotonin reuptake inhibitor. It is approved by the U.S. Food and Drug Administration (FDA) for treating major depressive disorder in adults and adolescents, as well as generalized anxiety disorder in adults. Escitalopram is sold under the brand names Lexapro and Cipralex.

Jul 1, 2017 · The most commonly prescribed class of medication for insomnia is the so-called z-drugs, zaleplon (Sonata), zolpidem (Ambien), and eszopiclone (Lunesta). 21 Numerous trials have demonstrated the... Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses). Hydroxyzine is an antihistamine.Feb 29, 2024 · Dosage. Side effects. Interactions. FAQ. What is trazodone? Trazodone is an antidepressant that belongs to a group of drugs called serotonin receptor antagonists and reuptake inhibitors (SARIs). Trazadone and mirtazapine both made my insomnia even worse. I stayed up like 2 days straight from 100 mg Trazodone and felt really weird. Seroquel wouldn't work unless I took 100- 200mg and then even if I slept 8-10 hours I was still a zombie. Hydroxizine worked for a while.hydrOXYzine QUEtiapine. Applies to: hydroxyzine and Seroquel (quetiapine) Using QUEtiapine together with hydrOXYzine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT ...

Trazodone is an antidepressant medication. It’s FDA approved to treat depression, but it’s more often used off-label for insomnia. When taken 30 minutes before bedtime, a low dose of trazodone (between 25 mg and 100 mg) may be effective for sleep problems. Trazodone is considered safe to take for short-term insomnia symptoms.Moderator. Hydroxyzine is an antihistamine (like Benadryl, but a whole lot stronger) with the side effect of causing most people to relax/sleep... It's often used during surgery with anesthesia, and post OP. Trazadone is another med that's used mostly for sleep. So I'd suspect that these are both intended as bedtime meds. Check with your doc ...Trazodone may also be used to treat other conditions such as problems sleeping, anxiety, and panic attacks. Buy Trazodone Tablets Online - Free Worldwide Shipping Trazodone is an oral state of mind elevator considered depression, anxiety (when it's a sign of misery), in addition to for agoraphobia, panic strikes and boosted aggressiveness.Applies to: trazodone and Effexor (venlafaxine) Using traZODone together with venlafaxine can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or ...

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Applies to: Klonopin (clonazepam) and hydroxyzine. Using clonazePAM together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of ...Discovered in the early 1800s from a chunk of smuggled platinum ore, rhodium is the most valuable precious metal on the planet today, used mainly for keeping car emissions in check...29 Jun 2022 ... Hydroxyzine, which is available as Vistaril and Atarax, commonly causes dizziness and fatigue. Some people also experienceTrusted Source these ...Trazadone and Hydroxyzine together. Hello! Last night after a particularly bad time getting back to sleep I took 100mg Trazadone and 50mg Hydroxyzine. I had a terrible reaction. I couldnt walk, see, or hear, and had major stomach issues. After doing some browsing it seems a lot of people mix the two together without any adverse affects.Serious side effects of Trazodone. Along with its needed effects, trazodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking trazodone: More common. Blurred vision ...

Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses). Hydroxyzine is an antihistamine.Applies to: doxepin and hydroxyzine. Using doxepin together with hydrOXYzine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to ...Dosage form: oral tablet (100 mg; 150 mg; 300 mg; 50 mg) Drug class: Phenylpiperazine antidepressants. Medically reviewed by Melisa Puckey, BPharm. Last …Taking Trazodone and Hydroxyzine together increases the risk of irregular heart rhythm to occur. Although this is rare and depends on the dose, it is still life-threatening. Moreover, the severity of QT prolongation can be increased when Trazodone and Hydroxyzine are combined. This is hydroxyzine, but it works very similarly to Benadryl.The usual hydroxyzine dose for adults with sleep problems is 50 mg per day, administered 30 minutes before bedtime. For doxylamine, the typical dose for insomnia is 25 mg per day, also taken 30 minutes before bed. Hydroxyzine and doxylamine haven’t been tested for long-term use in cases of insomnia. Applies to: Klonopin (clonazepam) and hydroxyzine. Using clonazePAM together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of ... Drug interactions are reported among people who take Hydroxyzine and Effexor. Common interactions among females include chronic kidney disease and constipation. Common interactions among males include pain and nausea. The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Effexor together.Trazodone hydrochloride is an antidepressant chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. Trazodone hydrochloride is a triazolopyridine derivative designated as 2-[3-[4-(m-Chlorophenyl)-1-piperazinyl]propyl] s-triazolo[4,3-a]-pyridin-3(2 H )-one monohydrochloride.It is a white orderless crystalline …This effect of SSRIs on alertness can be offset by sedative antidepressants such as trazodone, probably because they block 5-HT 2 receptors which are being overstimulated by an increase in 5-HT (Reference Kaynak, ... More profound effects on sleep have been reported for both promethazine and hydroxyzine, although neither is available over the ...Applies to: buspirone and hydroxyzine. Using busPIRone together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while ...

Trazadone and mirtazapine both made my insomnia even worse. I stayed up like 2 days straight from 100 mg Trazodone and felt really weird. Seroquel wouldn't work unless I took 100- 200mg and then even if I slept 8-10 hours I was still a zombie. Hydroxizine worked for a while.

Hydroxyzine and trazodone are both drugs that can cause irregular heart rhythms and dizziness. They can also interact with alcohol and other medications. Learn about the risks, precautions, and alternatives of using them together or alone. See moreThe following applies to the ingredients: Trazodone and Escitalopram (found in Lexapro) MONITOR CLOSELY: Concomitant use of agents with serotonergic activity including selective serotonin reuptake inhibitors, tricyclic antidepressants, and other antidepressants may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially …Go with Trazodone. Wanna go to sleep and simply calm mast cells, go with hydroxyzine. Trazodone gave me akathisia, depression, and anger issues the next day.Trazodone is an antidepressant medication commonly prescribed off-label for insomnia, with typical initial dosing at 25–100 mg before bedtime. In depressed patients, 150 mg is often the initial nocturnal dose. The dosage used in depression can be titrated upward, even up to 600 mg nightly, while closely observing blood pressure. SSRI with trazodone. Trazodone is a dual 5-HT 2A antagonist and serotonin reuptake inhibitor. Its 5-HT 2A blockade is believed to reduce the side-effects associated with the stimulation of 5-HT 2A, including sexual dysfunction, insomnia and anxiety. Trazodone has been largely used more for its sedative than its antidepressant properties. A printer registering as offline that appears to be online and properly set up can be a real nuisance, especially if it was working correctly just days ago. However, there are a lo... Trazodone and hydroxyzine. I experimented with hydroxyzine, but it took around three hours to take effect, providing only a sense of calm without inducing drowsiness. Dissatisfied, I informed my doctor, who then prescribed trazodone. I took it at 9:30 pm, and as of 11:34 pm, I haven't experienced any noticeable effects. Gabapentin, also known аs Neurontin, is an anticonvulsant medication used to treat seizures and nerve pain. It works by affecting chemicals and nerves in the body. Gabapentin is available in various forms, including …traZODone escitalopram. Applies to: trazodone and Lexapro (escitalopram) Using escitalopram together with traZODone can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, …Mar 2, 2021 · The type of drug taken also mattered. People who were on a long-acting benzodiazepine like diazepam (Valium) or flurazepam (Dalmane) were at greater risk than those on a short-acting one like triazolam (Halcion), lorazepam (Ativan), alprazolam (Xanax), or temazepam (Restoril). Why these drugs have a stronger effect in older people.

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Windows/Mac/Linux: Free personal organizer ThinkingRock helps you work David Allen's Getting Things Done methodology to the letter right on your desktop. Windows/Mac/Linux: Free pe...Alpha-1 blockers. Alpha-1 blockers, such as prazosin and doxazosin, are sympatholytics used for treating anxiety and PTSD. The greatest area for concern with this drug class in regard to myasthenia gravis is their potential to cause au-tonomic adverse effects, such as lightheadedness and or-thostatic hypotension.Hydroxyzine is an antihistamine that also does some stuff to serotonin, and trazodone is an antidepressant and serotonin antagonist that's also an antihistamine. After looking at the wiki pages for both, they seem pretty similar in terms of effects. For trazodone it says it is mostly a 5-HT2a antagonist at low doses.Dec 6, 2017 · Moderator. Hydroxyzine is an antihistamine (like Benadryl, but a whole lot stronger) with the side effect of causing most people to relax/sleep... It's often used during surgery with anesthesia, and post OP. Trazadone is another med that's used mostly for sleep. So I'd suspect that these are both intended as bedtime meds. Check with your doc ... JetBlue's hottest new vacation destination to welcome nonstop service from New York (JFK) is Puerto Vallarta (PVR) in Mexico. We may be compensated when you click on product links,...Using FLUoxetine together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications.The potential for adverse effects with hydroxyzine alone is noteworthy. Drowsiness and dizziness are fairly common, along with anticholinergic effects like dry mouth, urinary retention, and constipation. Less common but much more serious is the potential for cardiac QT-prolongation, which can precipitate serious heart rhythm problems.Trazodone is an antidepressant medication commonly prescribed off-label for insomnia, with typical initial dosing at 25–100 mg before bedtime. In depressed patients, 150 mg is often the initial nocturnal dose. The dosage used in depression can be titrated upward, even up to 600 mg nightly, while closely observing blood pressure.Hydroxyzine (Vistaril) 25 to 100: 2: 3 to 7: 37 (9 to 21) Anticholinergic, CNS depression/stimulation: No: Antidepressants: ... Trazodone is the most commonly prescribed sleep aid, but there is ...The American College of Obstetricians and Gynecologists (ACOG) has released guidelines on psychiatric medication used by women during pregnancy and lactation. The use of psychotropic medications ... ….

Dosage form: oral tablet (100 mg; 150 mg; 300 mg; 50 mg) Drug class: Phenylpiperazine antidepressants. Medically reviewed by Melisa Puckey, BPharm. Last …Experiences with trazadone/hydroxyzine? So a couple days ago I was prescribed these meds, 50mg trazadone every night and 25mg hydroxyzine as needed, like when I have anxiety attacks and/or flashbacks, or when I am overwhelmed for whatever reason. So far both have made me incredibly groggy and sleepy.Applies to: Klonopin (clonazepam) and hydroxyzine. Using clonazePAM together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of ...Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the mouth, stuffy nose, constipation, or change ...However, if trazodone has a role in preventing cognitive decline, it is important to consider whether that effect is mediated through its action in the UPR pathway, by … Hydroxyzine has an average rating of 5.7 out of 10 from a total of 1375 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 36% reported a negative effect. Mirtazapine has an average rating of 6.8 out of 10 from a total of 2023 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 21% reported a negative ... Hydroxyzine has an average rating of 5.7 out of 10 from a total of 1375 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 36% reported a negative effect. Mirtazapine has an average rating of 6.8 out of 10 from a total of 2023 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 21% reported a negative ...A subset of SRIs have U.S. Food and Drug Administration (FDA) indications for generalized anxiety disorder, including escitalopram and paroxetine among the SSRIs and venlafaxine and duloxetine among the SNRIs.Applies to: amitriptyline and hydroxyzine. Using amitriptyline together with hydrOXYzine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Trazodone and hydroxyzine, oxyCODONE OLANZapine. Applies to: oxycodone and olanzapine. Using narcotic pain or cough medications together with other medications that also cause central nervous system depression such as OLANZapine can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns., OBJECTIVE: While trazodone is approved for the treatment of depression, the off-label use of this medication for insomnia has surpassed its usage as an antidepressant. In this systematic review, we examined the evidence for the efficacy and safety of trazodone for insomnia. METHODS: A literature search was conducted using MEDLINE/PubMed ..., Trazodone is an atypical antidepressant.It's FDA-approved to treat depression in adults, but it isn't a first-choice option.In addition, trazodone is sometimes prescribed off-label for difficulty sleeping (insomnia).This medication is taken by mouth, typically once or a few times a day, depending on your condition.Common side effects of …, They had attempted to treat these symptoms with trazodone and zolpidem, without success. The psychiatric consultation liaison service was consulted to provide medication recommendations. ... and hydroxyzine, are frequently used for their sedative properties. Although this class of drugs is known for causing acetylcholine receptor …, Mexico’s Quintana Roo region, known for its spring break destinations of Cancun, Tulum, and Playa del Carmen, is loosening COVID-19 restrictions. The region of Quintana Roo in Mexi..., Experiences with trazadone/hydroxyzine? So a couple days ago I was prescribed these meds, 50mg trazadone every night and 25mg hydroxyzine as needed, like when I have anxiety attacks and/or flashbacks, or when I am overwhelmed for whatever reason. So far both have made me incredibly groggy and sleepy., Trazodone Interactions. There are 647 drugs known to interact with trazodone, along with 8 disease interactions, and 1 alcohol/food interaction.Of the total drug interactions, 136 are major, 496 are moderate, and 15 are minor. , a seizure (convulsions). Side effects such as drowsiness and confusion may be more likely in older adults. Common hydroxyzine side effects may include: drowsiness; headache; dry mouth; or. skin rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects., Among 36 patients trazodone receiving (n = 9), mirtazapine receiving (n = 8), hydroxyzine receiving (n = 8) and only SSRI receiving (n = 11) patients were compared to each other and to controls in ..., Summary. Sleep apnea is a sleeping disorder marked by interruptions in breathing during sleep. Certain medications, such as antihistamines, benzodiazepines, barbiturates, and opiates, can impact your natural sleeping cycle and breathing. This can increase your risk for developing sleep apnea or worsen the condition if you have it., Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses). Hydroxyzine is an antihistamine., Mirtazapine is used to treat depression. Mirtazapine belongs to a group of medicines called tetracyclic antidepressants. These medicines work in the central nervous system (CNS) to make certain chemicals in the brain stronger. This medicine is available only with your doctor's prescription. This product is available in the following dosage ..., 5 ounces of wine (12% alcohol) 1 1/2 ounces of liquor (40% alcohol) 12 ounces of beet (5% alcohol) The alcohol percent in the above drinks can certainly vary, but it gives you a good measuring stick. Therefore, if you have one drink, you want to wait at least one hour before taking trazodone. Two hours for two drinks, and so on., Several other antidepressants are also used off-label to treat insomnia, especially trazodone, which is typically prescribed at dosages of 50 to 100 mg at bedtime., Dry mouth, headache, constipation, diarrhea, and sexual dysfunction. Trazodone may cause a discontinuation syndrome if abruptly stopped, symptoms include anxiety, agitation, and sleep disturbances. When the time comes to withdraw trazodone, the dosage should be tapered off slowly under a doctor's advice., 14-C Urea breath test: Drug information; Abacavir and lamivudine: Drug information; Abacavir, lamivudine, and zidovudine: Drug information; Abacavir: Drug information , Experiences with trazadone/hydroxyzine? So a couple days ago I was prescribed these meds, 50mg trazadone every night and 25mg hydroxyzine as needed, like when I have anxiety attacks and/or flashbacks, or when I am overwhelmed for whatever reason. So far both have made me incredibly groggy and sleepy., US Pharm. 2010;35(11):HS-16-HS-21. A potentially lethal condition, serotonin syndrome (SS) is caused most often when certain antidepressant agents are taken concurrently with other drugs that modulate synaptic serotonin levels. 1,2 When patients take two or more antidepressants from different pharmacologic classes, drug-drug interactions may occur; …, Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. phenytoin. trazodone increases levels of phenytoin by unspecified interaction mechanism. , Trazadone and mirtazapine both made my insomnia even worse. I stayed up like 2 days straight from 100 mg Trazodone and felt really weird. Seroquel wouldn't work unless I took 100- 200mg and then even if I slept 8-10 hours I was …, Apr 22, 2020 · The only interaction between trazodone and hydroxyzine is that they both can cause sedation and drowsiness, and so the two may have an additive effect. Yes, that's fine, they just automatically offer the phone call, we can keep messaging here. Understand, so I I put some time like an hour between the Traz and hydroxyzine it will be ok.. , The usual hydroxyzine dose for adults with sleep problems is 50 mg per day, administered 30 minutes before bedtime. For doxylamine, the typical dose for insomnia is 25 mg per day, also taken 30 minutes before bed. Hydroxyzine and doxylamine haven’t been tested for long-term use in cases of insomnia., In pooled results, trazodone monotherapy appeared more likely than placebo to lead to a ‘positive treatment response’, although this difference was not statistically significant (37% vs 20%; relative benefit increase, 1.6; 95% confidence interval, CI, 0.8–3.3). Subgroup analyses suggested that men with psychogenic ED might be …, Retirement is an exciting new chapter, but it can be a tough transition. Here are 10 reasons why you may rethink retirement once you've left the workforce. We may receive compe..., Dosage. Side Effects. Warnings and Interactions. Trazodone is an antidepressant in the serotonin modulators class of drugs. It is used to treat depression and works by increasing the action of serotonin in your brain. In addition to being used for managing depression, it can be used to treat insomnia and anxiety., Trazodone and hydroxyzine. I experimented with hydroxyzine, but it took around three hours to take effect, providing only a sense of calm without inducing drowsiness. Dissatisfied, I informed my doctor, who then prescribed trazodone. I took it at 9:30 pm, and as of 11:34 pm, I haven't experienced any noticeable effects. , Mechanisms of action of gabapentin. Gabapentin is an anticonvulsant drug that reduces synaptic transmission by decreasing presynaptic voltage-gated Ca 2+ and Na + channels. 2 – 4 Besides, gabapentin reduces exocytosis and the discharge of neurotransmitter from presynaptic terminals. 5, 6 On the other hand, another line of …, traZODone escitalopram. Applies to: trazodone and Lexapro (escitalopram) Using escitalopram together with traZODone can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive ... , Although sedative antidepressants (e.g., trazodone, amitriptyline, mirtazapine) have been used in patients with depression complicated by insomnia, double-blind placebo …, Hydroxyzine; Trazodone; Gabapentin; Ramelteon; Doxepin; When you join the program, our expert will thoughtfully select two medications based on your case. Your doctor will also schedule routine online consultations and adjust the treatment if you’re experiencing sleepless nights after starting your treatment and avoid the risk of …, Iterax is a first-generation antihistamine that is used to treat allergies and anxiety. Due to its sedative effects, it is sometimes used to pre-medicate patients prior to surgery...., dizziness. fainting. fast heartbeat. hives, itching, or skin rash. irregular or slow heart rate. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. trouble breathing. unusual tiredness or weakness. Get emergency help immediately if any of the following symptoms of overdose occur:, Trazodone interactions may occur with other prescription and OTC medications and supplements. Trazodone can also interact with substances like alcohol. These interactions can raise your risk of serious medical issues like serotonin syndrome, bleeding problems, and heart rhythm problems.